Harry Kane is a serious doubt for England's match against Belgium on Sunday.
It comes after suffering from muscle tightness towards the end of the training session late on Saturday.
It follows a series of barbs between Gareth Southgate and Jose Mourinho, with Kane integral to both club and country.
But Mourinho's biggest fears may have been realised with the 27-year-old's fitness in doubt for Tottenham's clash on Sunday against West Ham.
And to make matters worse, Spurs have had a request for the striker to return to the club rejected.
Kane, as the country's skipper, is still with the England group.
But the chances of him playing against Belgium in a Nations League match is low.
The Red Devils are ranked as the best side in the world and have not lost a match in two years.
If Kane does not make it, Dominic Calvert-Lewin could step up after starring for the Three Lions against Wales.
On his national debut, the Everton ace led the line brilliantly – grabbing a goal on his international debut in the process.
Whether or not Kane returns to fitness for Tottenham's London derby next weekend may not even matter in Mourinho's eyes.
The Portuguese has continually asked for coaches to go easier on him considering his heavy workload and injury history.
It was only January when Kane suffered a serious hamstring tear that would have ruled him out of the European Championships had they not been postponed.
He did not take part in England's friendly against Wales on Thursday night.
The Walthamstow-born star has scored 32 goals in 47 appearances for England.
Tottenham have signed Carlos Vinicius from Benfica on loan, with an option to buy, to alleviate some of the workload on Kane.
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Spurs have signed strikers as back-ups before, though, with little success – with Vincent Janssen one example.
Despite signing for £17m in 2016, the Dutchman scored just two league goals – both from the penalty spot.
A miserable loan spell at Fenerbahce followed before a bizarre move to Mexico, where he still plays for Monterrey.
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